Cancer Of The Hypopharynx

image
What is the Hypopharynx?
What is Cancer of the Hypopharynx?
What are the causes of Hypopharyngeal Cancers and how can Hypopharyngeal Cancers be prevented?
How does Hypopharyngeal Cancer present?
How are Hypopharyngeal Cancers detected?
What are staging and grading?
How is Hypopharyngeal Cancer treated?
What are the side effects of treatment for Hypopharyngeal Cancer?
What is the importance of follow up?
image
  Previous

 

 

 

 

 

 

What is the Hypopharynx?

image
The hypopharynx is the last part of the throat or the pharynx. This is a 5-inch hollow tubing extending from behind the nose and going down to become part of the food pipe or the oesophagus. Air and food pass through the pharynx from the way on to the windpipe(trachea) or the oesophagus respectively.
Cancer in the Hypopharynx with a Metastasis to the Neck. (Lower image)
Cancer in the Hypopharynx with a Metastasis to the Neck. (Lower image)
 
image
Top Next

 

 

 

 

 

 

 

What is Cancer of the Hypopharynx?

image
Cancer of the hypopharynx is a cancer which originates in the hypopharynx and usually the cells of origin are squamous cells, which are flat, scaly cells. Thus, these cancers are usually squamous carcinomas but they could also be lymphomas, that is non-Hodgkin's lymphomas. When hypopharyngeal cancer spreads, it usually travels through the lymphatic system. Cancers that spread through the lymphatic system are carried along by lymph, which is a colorless watery fluid containing cells that help the body fight infection and disease. Lymphatic channels pass through various stations called lymph nodes, which are small bean-shaped organs located in groups in various parts of the body, such as in the neck, the armpits, the groin and inside the abdomen, and the central part of the chest. Cancers which originate in the hypopharynx and lodge themselves distantly in other organs are still known as metastatic hypopharyngeal cancers.

image
Top Previous Next

 

 

 

 

 

 

 

 

What are the causes of hypopharyngeal cancers and how can hypopharyngeal cancers be prevented?

image
There are several factors, which have strong links with the production of hypopharyngeal cancers.

The first and most important factor is tobacco abuse. Cigars, pipes, cigarettes, or chewing tobacco, dipping snuff, or using betel leaf with betel nut account for 80% to 90% of hypopharyngeal cancers. Because these habits are extremely prevalent in our country, nearly 33% of cancers in the Indian subcontinent are head and neck cancers, including hypopharyngeal cancers.

Studies have shown that smokeless tobacco users such as gutkha users, betel nut and betel leaf users, and tobacco chewers are at particular risk of developing hypopharyngeal cancer. For long-time users, the risk is extremely great, making the use of snuff or chewing tobacco amongst young people a very special concern.

People who stop using tobacco, even after many years of abuse, definitely benefit and greatly reduce the risk of developing hypopharyngeal cancers.

Chronic and heavy use of alcohol also increases the risk of hypopharyngeal cancer, which is extremely potentiated if the person also happens to be a smoker.

image
Top Previous Next

 

 

 

 

How does Hypopharyngeal Cancer present?

image
The usual ways in which hypopharyngeal cancers present are as follows:
A sore throat that does not go away or a feeling that something is 'caught in the throat'.
Difficulty or pain while chewing or swallowing.
A change in the voice or pain in the ear.
These symptoms can also be caused by other less serious problems. It is important that an ENT surgeon be shown as early as possible.

image
Top Previous Next

 

 

 

 

 

 

 

How are Hypopharyngeal Cancers detected?

image
Direct laryngoscopy is a specific investigation in which a self-lit or indirectly lit metallic tube is inserted into the patient's nose or mouth. This tube is called a laryngoscope. As the tube descends down the throat, the doctor can look at areas that cannot be seen with the simple mirror used in indirect laryngoscopy. A local anesthetic eases discomfort and prevents gagging, but many patients may have to get this test done under general anesthesia. Thus this test may be done on an OPD basis or after admission in a hospital.

If the doctor visualizes any abnormalities, he performs a biopsy, which is the removal of a small piece of representative tissue. This tissue piece is then forwarded to a pathologist to examine under a microscope to rule out the presence or absence of cancer.

Barium swallow is a special radiological imaging test in which the patient is made to swallow the contrast dye barium sulfate and the x-rays of the throat and the esophagus are taken. Any minute changes in the lining of the hypopharynx may be picked up by this test.

image
Top Previous Next

 

 

 

 

 

 

 

What are staging and grading?

image
These are terms with which you must become familiar, if you are dealing with any form of cancer.

When we stage a cancer, we try to establish carefully degree of spread of the cancer and if indeed there is spread, to what extent and involving which organs.

The grading of a cancer is a microscopic issue, in which the pathologist lets you know how aggressive this particular type of cancer is ; well differentiated means less aggressive, moderately differentiated intermediately aggressive and poorly differentiated more aggressive.

Both grading and staging help your clinician to establish the prognosis or how serious your disease is, and what is going to be the likely outcome.

Staging may require additional imaging tests such as CT scan, MRI, sonography, bone scan, or chest x-ray.

Specific stages for hypopharyngeal cancer are as follows:

Stage I: The disease is only in one part of the hypopharynx and has not spread to the lymph nodes in the area (Lymph nodes are small bean-shaped structures, which act as stations for drainage of lymph, a clear watery fluid, which courses through out the body in transparent, thin tubes called lymph channels or lymphatics, from various organs).

Stage II:
It has spread to more than one part of the hypopharynx or has spread to tissues adjacent to the hypopharynx but has not grown into the voice box or the larynx. There is no involvement of the lymph nodes.

Stage III: Out of all the following criteria, if one is satisfied.
The disease has spread outside the hypopharynx to the soft tissues of the neck and the lymph nodes in the area may or may not contain cancer.
The cancer is in the hypopharynx or has spread to the tissues adjacent to the hypopharynx. The cancer has spread to greater than one lymph node on the same side of the neck as the cancer or to lymph nodes on both sides of the neck or to any lymph node that is greater than 6 cm.
The cancer has spread to distant parts of the body.
Recurrent hypopharyngeal cancer This is a disease which has come back after the primary therapy for the hypopharyngeal cancer is over. It may recur in the hypopharynx itself or in other parts of the body.

image
Top Previous Next

 

 

 

 

 

 

 

How is Hypopharyngeal Cancer treated?

image
A lot depends on the patient's constitution, the grade of his disease, and its staging. Patients are usually treated by a team of specialists, which utilizes a multipronged approach. This includes an otorhinolaryngologist (ENT surgeon), a surgical oncologist, a reconstructive or plastic surgeon and a radiotherapist. The plan of treatment is tailored to fit a patient's requirements. If necessary, chemotherapy may become an add-on.

Treatment strategies:

The bastions of treatment for hypopharyngeal cancer are radiation therapy and surgery.

Surgery is the commonly employed treatment for localized lesions of the hypopharynx. The surgery, which is usually performed is called gastric pull up or a laryngopharyngectomy (removal of the larynx and the pharynx with pharyngo-gastrostomy, where the stomach is pulled out from inside the abdomen through the chest wall and to the neck and is joined with the pharynx). The lymph nodes in the neck may also be removed by dissection. This is quite an extensive surgery, which has to be done by skilled hands. The windpipe or trachea now opens to the outside through a permanent hole in the neck called a tracheotomy.

The alternative local therapy to surgery is radiation therapy. This involves the use of high energy, penetrative rays to destroy cancer cells. It affects cancer cells only in the zone treated. Radiation therapy is also employed for palliation i.e. control of symptoms alone in an advanced cancer.

Radiation therapy can also be used in adjunct to surgery or chemotherapy, either before or after.

Teletherapy or external radiation is given via a machine remote from the body while brachytherapy or internal radiation is given by implanting a radioactive source within the involved tissues. Patients may or may not require both modalities of radiation.

Radiotherapy, after initial planning, usually takes just 5 to 10 minutes per day, 5 days a week for about 6 weeks. This time period is flexible depending upon the modality of radiation used.

Besides local therapy, the best attempt to control cancer cells circulating in the body and lodged at places other than the soft tissues is by using systemic therapy (therapy which affects the entire systems of the body) which is in the form of injections or oral drugs. This form of treatment is called chemotherapy.

This form of treatment is given in a cyclical manner (each set of drugs is repeated usually after every 3-4 weeks).

Chemotherapy can also be used in combination with surgery, radiotherapy or both, either before or after.

For Stage I hypopharyngeal cancers, the procedures are:
Laryngopharyngectomy or surgery followed by radiation or radiotherapy alone.
For Stage II hypopharyngeal cancers, the procedures are:
Laryngopharyngectomy and lymph node dissection in the neck, followed by radiation.
Chemotherapy as a neoadjuvant ( that is, given before surgery) followed by radiation therapy.
For Stage III hypopharyngeal cancers, the procedures are:
Surgery and radiation or chemotherapy as a neoadjuvant, followed by surgery.
Radiation.
Chemotherapy and radiation alone.
For Stage IV hypopharyngeal cancers, the procedures are:
If the disease is amenable for surgery, which is usually unlikely, then surgery and radiation.
Neoadjuvant chemotherapy followed by surgery or radiation.
Chemotherapy combined with radiotherapy.
Radiation therapy with or without chemotherapy.
For Recurrent hypopharyngeal cancer, the procedures are:
Surgery to remove the cancer.
Radiation therapy.
Chemotherapy.

image
Top Previous Next

 

 

 

 

 

What are the side effects of treatment for Hypopharyngeal cancer?

image
Unfortunately treatment for cancer does cause damage to the healthy tissues.

Please ask the clinician about any possible side effects before any form of treatment commences.

For a few days after surgery, the patient is neither able to eat or drink and usually is fed intravenously. The patient may also have, as an alternative in some institutes, a nasogastric tube which is a small PVC tube inserted through the nose into the stomach at the time of surgery. Feeding through the nasogastric tube continues until there is sufficient evidence of healing of the surgical area, in which case the nasogastric tube is removed and the patient can feed in the normal manner.

After the surgery, the lungs and the windpipe, which have been subjected to a great deal of irritation, produce a tremendous amount of mucus, which is expectorated by the patient in the form of sputum. The nursing staff and the residents of the hospital may apply gentle suction with a small plastic tube placed in the stoma regularly to remove the sputum which, if it thickens and forms crusts, may drastically decrease the quality of breathing.

Eventually, the patient learns to cough out the sputum or to suck it out himself with a suction tube without the help of any nursing staff. The patient may also have to get the saliva sucked out from his mouth because the swelling in the throat prevents swallowing. All these are, however, just temporary phenomena.

Usually, the nose and the throat and the oral cavity moisten the air when it goes to the windpipe. Because this entire route has been short-circuited by the tracheostomy; there is no natural mechanism by which the air which is being inhaled can be moistened. If this is not done,then the lungs are exposed to dry air, which is a severe irritant. Therefore, an artificial way has to be employed to moisten the air, which is now entering through the tracheostomy. Patients are usually kept comfortable with a device, which adds moisture to the air. This device is called a humidifier.

A layrngopharyngectomy which has been associated with some form of neck dissection, may make parts of the neck and throat feel numb because nerves have been cut. There may also be a stiffness and weakness around the shoulder and neck.

Of course, the power of natural speech is gone for ever, and some artificial method may have to be adopted.

The effects of radiation depend upon the dose of radiation, the size of the area radiated, and the number and size of each fraction.

The commonest side effect is extreme fatigue. Although bed rest is good, most radiotherapists advise the patient to be as mobile as possible.
Another common problem is that of radiation dermatitis in which the skin covering the radiated area becomes red, dry, itchy, and may show signs of scaling off. This will slowly settle down after radiation ceases, but there may be a permanent 'bronzing' of the skin. It is important to note here that this skin problem is associated only with teletherapy or external radiation therapy.

Radiation also may cause nausea and vomiting, diarrhea, urinary discomfort.
There may also be a fall in the white blood cells, which are needed by humans to fight infection.

Usually the radiotherapist can suggest the drugs and diet necessary to alleviate such problems.

The various drugs used in chemotherapy cause a varied spectrum of side effects. The severity and variability of these symptoms are very individualistic, changing from patient to patient.

Some of the common side effects are:
Skin rashes.
Loss of hair.
Diarrhea.
Vomiting.
Tingling and numbness in the fingers and toes.
Hearing loss.
Most are temporary and recede after therapy is over. Hair growth gradually starts after cessation of chemotherapy.

The medical oncologist (chemotherapist) will usually be able t reduce he severity and spectrum of these side effects.

The psychology of the patient is very important during therapy. The better psychologically prepared the patient is, the better are his or her chances of having decreased side effects.

image
Top Previous Next

 

 

 

 

 

What is the importance of follow up?

image
The importance of followup cannot be overemphasized. It is a fatal fallacy to assume on the patient's part that once the primary or the first phase of treatment is over, then he or she is cured. It must be stressed here that cancer has a notorious proclivity of coming back again and again. The only way to fight this is to pick up any problem when it is still early, so that it can be nipped in the bud. And the only way to do this is to follow up when the doctor calls you for the next visit. Each such visit will include a detailed history, a physical examination (including an internal i.e. a rectal or vaginal examination ), a chest x-ray, an ultrasonography or a CT scan, and various other blood studies as indicated.

image
Top Previous